A pass interference penalty against Bill Bentley set up Rashard Mendenhall's 1-yard touchdown run with 1:59 to play Sunday and Arizona beat the Detroit Lions 25-21 in Bruce Arians' home debut as Cardinals coach.
Jay Feely kicked four field goals and Carson Palmer threw a 36-yard touchdown pass to rookie Andre Ellington for Arizona (1-1). Ellington also had a 16-yard catch to start the deciding drive.
Matthew Stafford connected with Calvin Johnson on touchdown plays of 72 and 3 yards, and DeAndre Levy returned an interception 66 yards for a score for Detroit (1-1), which led 21-13 midway through the third quarter.
Arizona's Larry Fitzgerald played despite a sore hamstring but was unable to finish the contest. Detroit's Reggie Bush injured his left knee in the first half and played only briefly in the second.