Indiana found a combination that worked and stayed with it.
Eric Gordon scored 25 points, D.J. White added 22 and the No. 9 Hoosiers, keeping the same lineup the entire second half, wore down invading Penn State 81-65 on Sunday.
In Sunday's other Big Ten game, Michigan State won 78-73 at Minnesota.
In Saturday's games: No. 17 Wisconsin beat Northwestern 62-50 at Madison; Purdue had a 74-67 home-court win against Illinois; Tennessee downed visiting Ohio State 74-69; and Iowa won 68-60 at Michigan.
"It was a slow-paced game. They were zoning us," Indiana coach Kelvin Sampson said. "Usually you make a substitution for fatigue or for foul trouble. But I liked the way they were playing, so I saw no reason to make a substitution."
The Hoosiers (16-1, 5-0 Big Ten) won their 27th straight home game and stretched their winning streak this season to 12 games, their longest in 15 years.
Penn State (10-7, 2-3), which lost leading scorer and rebounder Geary Claxton with a season-ending knee injury against Wisconsin on Tuesday, came out strong, stayed with the Hoosiers most of the game and led 52-51 before a 3-pointer by Gordon started a 14-4 run that put Indiana in control. White had Indiana's next five points and assisted on another basket by Jamarcus Ellis, and the Hoosiers began pulling away for good.
Meanwhile, Drew Neitzel found his touch just in time for Michigan State.
Held to two points in the first half and struggling through a shooting slump in the first four games of the Big Ten season, Neitzel made five 3-pointers in the final 20 minutes to lead No. 11 Michigan State past Minnesota.
Neitzel finished with 19 points and reserve Kalin Lucas added 12 points for the Spartans (16-2, 4-1), who shook off 18 turnovers to win their second in a row following a woeful 36-point effort at Iowa last week.
Lawrence McKenzie had 20 points for the Gophers (12-5, 2-3), who are still looking for their first quality win under new coach Tubby Smith.
In Wisconsin's victory Saturday night, Marcus Landry became the fifth different Badger player to lead the team with at least 20 points in the team's first five Big Ten games.
The Badgers' leading scorers in their first four Big Ten games were Jon Leuer (25 points vs. Michigan), Brian Butch (22 vs. Iowa), Trevon Hughes (22 vs. Illinois) and Michael Flowers (23 vs. Penn State). All but Leuer are starters.
The Badgers (15-2, 5-0 Big Ten) used a 13-2 run at the start of the second half to break open a close game.
Landry scored 15 of his points after halftime, including five during the opening stretch of the period when the Badgers pulled away.
Michael Thompson led Northwestern (6-9, 0-5) with 16 points.
Earlier, Keaton Grant scored 22 points, Nemanja Calasan added 17 and Purdue used a 20-3 second-half run to rally past Illinois.
The Boilermakers (13-5, 4-1 Big Ten) trailed by nine points in the first half and again early in the second before the Illini (9-10, 1-5) went cold. Robbie Hummel, scoreless in the first half, had eight of his 13 points during Purdue's big run, and a basket by Calasan gave the Boilermakers their first lead of the game, 43-42.
A basket by Hummel and six straight points by E'Twaun Moore then helped push Purdue's lead to 51-43 and the Illini never recovered.
A 3-pointer by Trent Meacham pulled Illinois within 58-55 with 5 minutes to go, but Calasan hit three free throws, Grant added two more and then hit a clinching 3-pointer with under 2 minutes remaining.
Grant's 22 points matched the most by any Purdue player all season.
Shaun Pruitt and Brian Randle led Illinois with 15 points each, while Meacham added 11.
Purdue never led in the first half, missing nine straight shots over the opening 5 1/2 minutes before the initial wave of substitutions helped produce three quick scores by the Boilermakers.
In the win at Knoxville, Tyler Smith made two free throws with 11 seconds left and No. 6 Tennessee got some small revenge for its NCAA tournament loss to Ohio State last season.
JaJuan Smith scored 15 points, Chris Lofton added 13 and Tyler Smith and Ramar Smith both had 12, helping the Vols (16-1) to only their second 16-1 start ever. Tyler Smith grabbed 7 rebounds.
Before Evan Turner's foul sent Tyler Smith to the line, Jon Diebler missed two 3-point shots that would have tied the game, with Tyler Smith rebounding the second. Jamar Butler and Kosta Koufos both missed shots after Smith's foul shots.
The Buckeyes (12-6) led 46-39 on a jumper by Othello Hunter with 15:55 left, capping a 16-6 Ohio State run. But Ohio State went cold as Tennessee took off on a 27-6 run.
Turner had 21 points and 10 rebounds for the Buckeyes, while Hunter had 17 points and 14 rebounds, Koufos added 13 points and David Lighty had 10 points.
Later, at Ann Arbor, Tony Freeman scored a career-high 28 and Cyrus Tate had career highs with 21 points and 11 rebounds, leading Iowa past Michigan.
The Hawkeyes (9-10, 2-4 Big Ten) took control of the game with a 12-1 run early in the second half after leading by two at halftime and the cushion helped hold off a late Michigan rally.
DeShawn Sims had 18 points, Jevohn Shepherd scored a career-high 11 -- all in the first half -- and Manny Harris added 11 for the Wolverines (5-13, 1-5).
Michigan trailed by 13 points late in the game, but pulled within four with 1:22 left after Harris made a four-point play following consecutive 3-pointers from Sims and Kelvin Grady.
Iowa responded offensively and Harris turned the ball over in his backcourt with 1:16 to go, hurting Michigan's comeback chance.