The ticket matches 5 of the 6 winning numbers from Tuesday night's record-breaking jackpot drawing.
It's worth $250,000 and it was sold at the Kroger in St. Johns.
The Michigan Lottery, as of 4 p.m., says it has not been claimed.
Neither have two other $250,000 tickets, sold in Detroit.
At the Kroger store, the store manager, Brian Bremer, says many people came to check their tickets against the numbers when they heard. They are hopeful it's a regular customer who's won.