The robbery happened just before 8 p.m. at DJ's Corner Market, 1300 E. Main St. in Lansing.
Police say one of the suspects shot the storeowner once through the chest. He and another man then got away with an unknown amount of money.
The owner is in critical condition in the hospital undergoing surgery.
Police are now looking for two suspects in the case. They say one of them is a black male, 5'5" to 5'7", 150 lbs., wearing a blue-hooded sweatshirt. The second suspect is a black male wearing dark clothing.
Anyone with information is asked to call Lansing Police at (517) 483-4600.